Human Metapneumovirus: A comprehensive review
Harpreet Kaur
, Dr. Paras Monga , Wahid Ahmed
Human metapneumovirus; Paramyxovirus; Bronchiolitis; Pneumonia
Human metapneumovirus (hMPV) is linked to upper and lower respiratory tract infections, that mostly infect the immunocompromised people, children , elderly individuals. Five to ten percent of children who are hospitalized for acute respiratory tract infections have diagnosed with hMPV, which can cause serious infections like pneumonia and bronchiolitis. They are identical to infections brought on by the human respiratory syncytial virus. The first hMPV infection occurs during early nonage , but reinfections are common throughout life, especially in aged subjects. HMPV has a seasonal variation it circulates in late downtime to early spring in temperate climates, late spring and summer in tropical regions. hMPV is veritably delicate to insulate using cell culture. Till now, the only way for hMPV opinion was the TS – CRP assays Rear recap polymerase chain response(Reverse transcriptase polymerase chain reaction) is the most sensitive test with which to descry hMPV infection. Direct discovery of hMPV antigens with an immunofluorescent antibody test is available but is less sensitive than PCR. Antibody testing is used substantially for retrospective opinion and for epidemiological studies. The dependence of treatment of hMPV infections is probative. Promising experimental models have been developed to more understand hMPV pathogenesis and to estimate the implicit effect of different remedial modalities. No marketable treatments are yet available for hMPV, although ribavirin has shown exertion both in vitro and in beast models. Monoclonal antibodies have exertion in murine models but are not available in humans. Several vaccines are promising in beast models, but their safety and efficacity have not yet been estimated in humans.
Volume 3
Issue 5,
May-2025
Pages : 1-12
Paper Reg. ID: JAAFR_500381
Published Paper Id: JAAFR2505001
Downloads: 000144
Research Area: Pharmacy All
Country: Fatehgarh sahib, Punjab, India
ISSN: 2984-889X | IMPACT FACTOR: 9.87 Calculated By Google Scholar | ESTD YEAR: 2023
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.87 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: JAAFR (IJ Publication) Janvi Wave
